TARGETING SET TO RESTORE PP2A ACTIVITY DISRUPTS AN ONCOGENIC CIP2A-FEEDFORWARD LOOP AND IMPAIRS TRIPLE NEGATIVE BREAST CANCER PROGRESSIONRESEARCH IN CONTEXT

Background: Triple-negative breast cancer (TNBC) remains difficult to be targeted.SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in cancers, whereas reactivating PP2A activity has been postulated as an anti-cancer strategy.Here

The objective of this work was to evaluate yield and average fruit weight of strawberry cultivars Albion, Camarosa, Festival and Oso Grande, in two closed hydroponic systems (gutters and grow bags), using coconut fibre as substrate.The experimental design was of randomised blocks, divided into strips, with five replications.The hydroponic systems d

Biomonitoring methods based on macroinvertebrate assemblages are widely developed in streams and rivers.However, the use of invertebrates has been criticized due to FRAMED PRINT the long time and expense of processing samples.Therefore, we evaluated the effectiveness of reducing the sampling effort from 20 to 5 samples to assess the stream macroinv

The debris flow is one of the geological hazards; its occurrence is complex, fuzzy, and random.And it is affected by many indices; a new multi-index assessment method is proposed to analyze the risk level Walker of debris flow based on the entropy weight-normal cloud model in Banshanmen gully.The index weight is calculated by using the entropy weig